PRL2 links magnesium flux and sex-dependent circadian metabolic rhythms

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PRL2 links magnesium flux and sex-dependent circadian metabolic rhythms.

Magnesium (Mg2+) plays pleiotropic roles in cellular biology, and it is essentially required for all living organisms. Although previous studies demonstrated intracellular Mg2+ levels were regulated by the complex of phosphatase of regenerating liver 2 (PRL2) and Mg2+ transporter of cyclin M (CNNMs), physiological functions of PRL2 in whole animals remain unclear. Interestingly, Mg2+ was recent...

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ژورنال

عنوان ژورنال: JCI Insight

سال: 2017

ISSN: 2379-3708

DOI: 10.1172/jci.insight.91722